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Predominantly gastrointestinal nausea, diarrhea, vomiting, constipation, and decreased appetite all dose-dependent and most common after a dose or an escalation

Combining CagriSema (which contains semaglutide) with tirzepatide (which activates GLP-1 receptors) would result in excessive GLP-1 pathway stimulation, likely producing severe gastrointestinal side effects

Synergy in Action Combining these peptides creates a multiplicative effect: TB4 fragments enhance cell migration and tissue remodeling

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