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Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases

Production of antigen-specific IgE antibodies and disruption of the gut microbiota are the main features of OVA-induced immediate hypersensitivity

1991 Jun 1;95(6):641-55

High levels of oxidative stress and free radical damage leading to a severe inflammatory response

Future studies are needed to reconcile the underlying differences between tumor tissue and basal PTC cell line GPX4 expression levels and in vitro responses to pharmacologic inhibition of GPX4 within an emulated 3D thyroid tumor microenvironment in vitro and in vivo

doi: 10.1016/S0021-9258(18)98430-9 43 SaftigPHunzikerEEvertsVJonesSBoydeAWehmeyerOet al