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doi: 10.1016/j.jnutbio.2015.08.012

Our findings highlight the impact of metabolic reprogramming within the niche as metastases progress and suggest clinical potential for targeting this pathway in colorectal cancer

Moreover, the interaction between DNA methylation and various epigenetic mechanisms, such as non-coding RNAs and histone modifications, can be harnessed to create combinatorial epigenetic therapies that simultaneously target multiple regulatory layers, potentially improving treatment efficacy ( Even though these are good signs, there are still some big problems that need to be fixed before epigenetic therapies can be used regularly in AS

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