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In vitro, PPARdelta activation in adipocytes and skeletal muscle cells promotes fatty acid oxidation and utilization

Importantly, SFN can cross the blood-brain barrier effectively

Miller, Carl (27 September 2020)

doi: 10.1254/jphs.09292SC 167 PajoA

Many herbal compounds exhibit this dual potential through pleiotropic actions antioxidant, anti-inflammatory, and pathway modulation simultaneously protecting endothelium and promoting PASMC apoptosis