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The pigment neuromelanin (NM) is found at high concentrations in the SN and locus coeruleus (LC), where it is synthesised through polymerisation of dopamine-protein adducts 40

Science 261:10471051 Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

We thank constructive comments from Murray Bell and Janice Watson in Terminology Service in Public Health Scotland, and information provided by Allison Reid in the coding department in NHS Lothian, Paul Mitchell, Nicola Symmers, and Barry Hewit in Edinburgh Cancer Informatics, and staff in Epic Systems Corporation

doi: 10.1186/s13293-022-00476-6

(9Z,12Z,15Z)-Octadecatrienoic acid, also known as -linolenic acid, has multiple functions, including improving cardiovascular health, enhancing immunity, and providing anti-inflammatory effects (25)

But calibrating expectations to real-world rather than trial-level outcomes prevents disappointment