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Increased intestinal permeability has been identified as a factor in a wide range of conditions many of which, on the surface, appear to have nothing to do with the gut: IBS IBD: Ulcerative colitis & Crohn's disease Coeliac disease Type 1 and 2 diabetes Hashimotos thyroiditis Rheumatoid arthritis Alopecia Multiple sclerosis Parkinsons disease Polycystic Ovarian Syndrome (PCOS) Alcoholic liver disease Liver cirrhosis Acute pancreatitis Chronic heart failure Depression (2-5) Chronic Fatigue Syndrome / M.E Psoriasis Acne Long COVID Among many others

Thymalin , derived from thymus tissue, promotes T cell maturation and function through distinct mechanisms

Barak V, Birkenfeld S, Halperin T,Kalickman I

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Historical withdrawal studies reported headache, nausea, vertigo and episodes of hypotension

In a rat model of autism induced by intra-cerebro-ventricular (ICV) infusion of propionic acid, elevated levels of TNF- and IL-6 were normalized by oral administration of ethanolic extract of roots of CT in rat brain tissues