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Conclusion: While a significant increase in Ybx1 expression in differentiating preadipocytes may support healthy adipogenesis, our findings reveal a detrimental mechanism in which the maladaptive activation of Ybx1 within hepatocytes directly stimulates the C/EBP:PPAR pathway, leading to an increase in adipogenic gene expression that becomes lipotoxic within the liver

doi:10.1002/ncp.10234 [24] Ringseis R, Keller J, Eder K

Similarly, miR-141-3p accelerates OC progression by promoting cell proliferation, migration, and invasion while enhancing M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

doi: 10.1007/s00429-011-0308-y 115 ParkerA.RomanoS.AnsorgeR.AboelnourA.Le GallG.SavvaG

We used linear regression analyses to examine the associations of patients self-reported health status (terminally ill vs