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8 Discussion and prospects In recent years, with the rapid advancement of technologies such as metabolomics and single-cell sequencing, research on COPD has shifted beyond traditional focus on three classic mechanismschronic inflammation, oxidative stress, and protease-antiprotease imbalance

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Images were imaged at 300 kV with a magnification of 81,000, corresponding to a pixel size of 0.53

10.1021/cr050262p 89

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