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We found that 1095 patients (45.0%) reported at least 1 symptom, and the most common symptoms were fatigue, sweating, chest tightness, anxiety, and myalgia

Suppression of PC production by small interfering RNA (siRNA) impairs GSIS in both insulinoma cells [34, 35] and isolated rat islets [35], and also reduced cell proliferation [35], while overproduction of PC in INS-1 cells increases GSIS and cell proliferation [35]