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For example, Maffioletti et al

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These are mechanistically different agents at opposite ends of the regulatory ladder

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With poorly controlled or severe disease, there is risk that extra-articular manifestations such as keratitis, pulmonary granulomas (rheumatoid nodules), pericarditis/pleuritis, small vessel vasculitis, and other non-specific extra-articular symptoms will develop

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Further research suggest systematic healing of intestinal damage such as stulas, inammatory disorders, gastro-intestinal cramps, Crohns disease and leaky gut

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These include malignancy, sepsis, shock, cirrhosis, gall stones, drugs, and autoimmune hepatitis (Whitehead et al., 2001)

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It also summarizes recent advances in drug discovery, including natural compounds, synthetic activators, and NAD + precursors, and evaluates their translational potential for MASLD therapy

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