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To do so, measured M concentration of target metabolite in the erythrocyte fraction was divided on concentration factor after gradient

In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

Bernaerts S, Boets B, Steyaert J, Wenderoth N, Alaerts K

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-B, MAPKs, and Nrf2 signaling pathways in rats