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These might act peripherally (i.e., bile duct ligation), centrally (i.e., huge intraventricular hemorrhage), and then peripherally and centrally, and centrally and peripherally, along with the three interconnected body cavities, as specifically shown in the maintained intra-abdominal hypertension studies [22], as the disturbances may be rapidly transmitted from the periphery to centrally, and from centrally to the periphery, through the venous system

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doi: 10.15252/embj.201796516 117 KomoriM.LinY

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These included nausea, diarrhea, vomiting, constipation, and decreased appetite