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However, letrozole, anastrozole, and exemestane are newer-generation AIs that dominate the drug category

4.1.3 Mice and in vivo experiments All animal experiments were approved by The Institute of Cancer Research Animal Welfare and Ethical Review Body and performed in accordance with the UK Home Office Animals (Scientific Procedures) Act 1986, the UK National Cancer Research Institute guidelines for the welfare of animals in cancer research and the ARRIVE (animal research: reporting in-vivo experiments) guidelines

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doi:10.1136/practneurol-2014-001071

Additionally, it has a specialized, inducible signaling function, where the PKA-HSL axis in M2 cells is highly activated to produce specific mediators that coordinate the complete pro-resolving program