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Litvinov RI, Weisel JW

Mutation burden and trinucleotide substitution profiles Given the biases in the creation of restriction-enzyme NanoSeq libraries, resulting from trinucleotides overlapping the restriction enzyme site, a correction for sequence composition is applied to each of the 96 possible trinucleotide substitutions as detailed in the methods for the original publication 32

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Techniques and pitfalls in the detection of pathogenic mitochondrial DNA mutations

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Statistical Analysis Data are expressed as mean SEM