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155 Additionally, targeting bile acid metabolism, such as through bile acid sequestrants and farnesoid X receptor agonists, has shown promise in preclinical models by reducing bile acid accumulation and hepatotoxicity

The cryoprobe is applied directly or immediately adjacent to the peripheral nerve of interest and creates localized freezing which induces axonotmesis in which Wallerian degeneration of the axon and myelin sheath occurs distal, and to a lesser extent proximal, to the lesion [19]

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Administration of AA and antidepressant medications to a patient population with hyperinflammatory responses, chronic oxidative stress, and mitochondrial dysfunction as aspects of their disease holds potential to reverse these states