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Due to its very low ability to synthesize and regenerate GSH, the brain is one of the most vulnerable tissues to excess ROS 15,21

The dual regulatory role of ATF4 is further reflected in its ability to influence antioxidant defenses

In retinal ganglion cells, this translates to preserved cell bodies and axons preventing glaucomatous vision loss

The final step in this pathway is the conversion of phosphocholine into phosphatidylcholine, a process catalyzed by the enzyme 1,2-diacylglycerol cholinephosphotransferase