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The disease spectrum varies enormously due to the interaction of AFs-induced oxidative stress, apoptosis, necrosis of proximal tubular epithelium, oxidative DNA damage, p53 disruption, bioactivation, disruption of regeneration fidelity [31, 32, 37], immune dysregulation, enhancement of neutrophil elastase-induced damage [32], epigenetic modification, disruption of protein synthesis, impairment of sound cellular regeneration, disturbed cell cycle in S phase, lipotoxicity, mitochondrial dysfunction, upregulation of micro RNA, autophagy, stimulation of transforming growth factor pathways, augmentation of Escherichia coli toxicity, dysbiosis [38], and others [28, 32, 38]

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The data indicate that the cases reporting a principal diagnosis of DVT and USAT with thrombolytic(s) appear to consume more resources in comparison to the ( other cases in MS-DRG 253, although it is unclear if the higher resource consumption is a direct result of the EKOS TM device technology utilized in the performance of the thrombolysis procedure, or the fact that these cases also include the reporting of at least one or more secondary CC diagnoses, or a combination of both factors