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Wu CW, Dionigi G, Barczynski M, Chiang FY, Dralle H, Schneider R, Al-Quaryshi Z, Angelos P, Brauckhoff K, Brooks JA, Cernea CR, Chaplin J, Chen AY, Davies L, Diercks GR, Duh QY, Fundakowski C, Goretzki PE, Hales NW, Hartl D, Kamani D, Kandil E, Kyriazidis N, Liddy W, Miyauchi A, Orloff L, Rastatter JC, Scharpf J, Serpell J, Shin JJ, Sinclair CF, Stack BC, Tolley NS, Slycke SV, Snyder SK, Urken ML, Volpi E, Witterick I, Wong RJ, Woodson G, Zafereo ME , Randolph GW

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55,56 Its pathogenesis is highly complex, involving the interplay of factors including lipid metabolism disorders, 57 insulin resistance, 10 oxidative stress, 58 immune activation, 13 and gut microbiota dysbiosis

However, rather than directly affecting FAO, SCAP deficiency suppressed regulation of genes involved in sterol biosynthesis, including critical enzymes such as 3-hydroxy-3-methylglutaryl coenzyme A reductase

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