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An analysis of six clinical trials found that AOD 9604 had a safety profile comparable to placebo and did not act through the IGF-1 pathway

Xie X, Liu H, Wang Y, Zhou Y, Yu H, Li G, Ruan Z, Li F, Wang X, Zhang J (2016) Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

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Early studies with GHdeficient individuals indicated the role of the hormone in the regulation of body composition

In aged mice treated for 8 weeks at 10 mg/kg daily, sedentary mice showed approximately 40% greater grip strength than controls, and when combined with exercise, grip strength improved by approximately 60%