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Elevated kynurenine levels are remarkably associated with insulin resistance and -cell dysfunction, potentially contributing to the pathogenesis of diabetes through mechanisms involving inflammatory responses and oxidative stress, influencing the pathological progression of CHD (77)

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Chalcone is the substrate for the enzyme chalcone isomerase, which is essential in the biosynthesis of secondary metabolites, such as flavonoids, tannins, and flavonols (Shirley Reference Shirley1996)

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Diabetes is a metabolic disorder marked by relative or absolute insulin secretion deficits leading to chronic hyperglycemia and carbohydrate, lipid, and protein metabolism abnormalities

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