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In addition, other delivery compositions of SiNPs in infectious disease treatment such as metal-silica nanocomposites, nitric oxide (NO) delivery, antibiofilm coatings and dental composites were also explored and are summarized in Supplementary Table 1

While some authors report that there is no difference in the relapse rate but simply a longer interval without relapse for the treatment of ulcerative colitis with probiotics such as Escherichia coli Nissle 1917 or Lactobacillus GG, others accept that supplementation of medical treatment with Bifidobacterium spp

Ameli and Alizadeh, 2022)

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Starting from day 14, the culture medium was replaced with Hepatocyte Maintenance Medium [Lonza Hepatocyte Culture Medium (HCM) composed of 500 ml 1X HBM Basal Medium and 1X HCM SingleQuots Supplement Pack (both from Lonza Group, Ltd.), supplemented with 20 ng/ml OSM (R&D Systems)]

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