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The move to self-inject, driven by the pandemic, has an "upside", claims Medina: it could ease the pressure on staffing shortages, as well as being more practical and convenient for patients

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Angle difficulty: The awkward angle required for self-injection in the upper arm increases the risk of injecting too shallow (intradermal, which causes a painful wheal) or too deep (intramuscular)

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Critically, longer-term use was not associated with any increased risk of cardiovascular events or death

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However, risk-benefit analyses often rest on the assumption that mRNA injection-induced spike protein expression is transient

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