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Mutations in the GBA1 gene which encodes the lysosomal enzyme glucocerebrosidase (GCase) constitute a major genetic risk factor for PD [201, 202], and recent experiments have demonstrated that GCase activity contributes to the clearance of -synuclein aggregates [203, 204]

The results showed that the application of Glu-Cys produced weak agonist activity, with an EC 50 value of 3204 1543 M and a max F/F0 of 0.42 0.07

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We found the remedial potential associated with these compounds individually based on the previous findings

doi: 10.1073/pnas.96.18.10039 52 WatkinsPAHowardAEMihalikSJ

However, this effect appears to be insufficient to elicit allergic responses without RAGE signaling