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Given the expansion of the AR cistrome and the emergence of novel AR binding sites under ADT, similar to observations during carcinogenesis, it is tempting to speculate that other factors acting at or near AREs may be in play in CRPC

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2020 Jan 1;25(1):182

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In this sense, glutamine-derived isotopologues such as citrate m + 5, aspartate m + 3, malate m + 3, and fumarate m + 3 are indicative of -ketoglutarate-isocitrate reductive reaction (with the incorporation of CO 2 )