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Realistic Cd burdens appear to represent a serious threat to honey bees in terms of development and survival and larval stages to be especially susceptible to the toxic effects of Cd

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For instance, the v6 splice variant of the hyaluronan receptor CD44 links c-MET signaling to the actin cytoskeleton via GRB2 and the ezrin, radixin and moesin (ERM) family of proteins in order to recruit SOS, which then amplifies RAS-ERK signaling [Orian-Rousseau et al

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