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First, the copper transport process cannot be accurately regulated

At the same time, it also causes an upregulation of expression levels of PD-L1 on the surface of cancer cells (Cobine and Brady, 2022

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Child 74 , 542545 (1996)

Flux along this pathway is likely to be increased under general conditions in which the mitochondrial NADH:NAD + ratio increases, which would include hypoxia and where there are deficiencies in NADH oxidation due to mitochondrial dysfunction