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The mode of cell death induced by these compounds was surprisingly found to be non-apoptotic, as cells treated with erastin and RSL3 died in the absence of apoptotic hallmarks [11, 12, 13], and in cells where the core apoptosis machinery caspases, BAX, and BAK was suppressed [14]

[14] These antidepressant effects have been linked to endogenous opioid peptides acting at - and -opioid receptors, [15] and so can also be produced by enkephalinase inhibitors such as RB-101

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Sample processing was conducted by one individual

Yang WY, Meng X, Wang YR, Wang QQ, He X, Sun XY, et al