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For Asn240Lys/Leu244Arg, the best docking poses suggest that all substrates can be orientated correctly within the active site since it exhibits the Phe260-substrate-His243 -stacking-system (Fig

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Although believed to be prevalent, the exact incidence is not known

Epilepsia 54 , 551563 (2013)

Yuki and Koutsogiannaki, 2021)