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The virus infects neurons and microglia which promotes the release of tissue tumor necrosis factor-alpha, cytokines (interleukin-6 (IL-6), IL-2, IL-5), and reactive oxygen species (ROS) 54 causing further stress and damage to the nervous system

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ClO reacts rapidly with glutathione to give products that glutathione reductase cannot reduce (Carr and Winterbourn 1997)

Mouse methionine sulfoxide reductase B: effect of selenocysteine incorporation on its activity and expression of the seleno-containing enzyme in bacterial and mammalian cells