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Preclinical evidence suggested that, similar to other anticancer drugs, the effectiveness of metformin was limited in in vitro studies and it is feasible to combine drugs to simultaneously target multiple metabolic pathways in NSCLC to improve treatment efficacy

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Specific concerns include theoretical copper exposure with repeated systemic dosing, a conceptual contraindication in Wilsons disease and other copper-metabolism disorders, and the sterility and impurity risks of injecting research-grade material that is not a sterile pharmaceutical product

TB-500, with its smaller molecular weight, distributes more systemically and supports healing throughout the body

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This also includes the gastric mucosa, where oral supplementation with PC has been shown to provide gastrointestinal support to damaged cells