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Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis

CRISPR screens are helping to identify new targets and learnings from years of using CAR-T to treat liquid tumors like leukemia are helping researchers design CAR-T therapies to tackle solid tumors.In the past few years, a number of clinical trials have begun testing CAR-T immunotherapy in patients whose disease is not adequately controlled with traditional treatments

A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization

Catalytic coupling of arene CH bonds and alkynes for the synthesis of coumarins: substrate scope and application to the development of neuroimaging agents

Hartley, D.P., D.J

10.1111/j.1471-4159.2009.06160.x 314 SchmitzG.EckerJ