glutathione pathway help Participation in the Prevention of Cardiovascular Diseases A mathematical model of glutathione

10.1186/s13024-023-00691-8 67 LiuC.PanJ.BaoQ

Cells were seeded at a density of 1 10 6 cells/mL and were cultured for 24 hours (n = 11) or 72 hours (n = 19) in RPMI-1640 medium supplemented with 10% human serum (Sigma-Aldrich) and penicillin-streptomycin (100 U/g/mL)

Epub 2022 Jul 28

Reduction in cerebrospinal fluid GABA levels and therapeutic response to GABA agonist treatment

Autopsy samples from individuals with secondary progressive MS (SPMS) showed NCOA4 expression in macrophages and oligodendrocytes at the mixed active/non-active lesion edge, with iron ferritin-positive cells and iron-containing cells present in this region

Brain-focused conclusions require an appropriate combination of neural tissue, cerebrospinal fluid, imaging, or mechanistic models