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Biomed Pharm 57:145155 Mailloux RJ, McBride SL, Harper M-E (2013) Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

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Immune cells, such as macrophages and neutrophils, can also generate ROS due to their oxygen-dependent mechanisms to fight against invading microorganisms based on NOX2 isoform ( ROS are produced in mitochondria during aerobic metabolism (Rodriguez and Redman, 2005)