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Hormone-derived peptide fragments and structurefunction relationships

The blockbuster weight loss medications that have transformed conversations about obesity and metabolic healthsemaglutide (Ozempic and Wegovy), tirzepatide (Zepbound or Mounjaro), and retatrutide (a newcomer on the block thats not yet FDA approved but highly anticipated for approval next year)are all peptide-based drugs

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4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Gao et al., 2021)

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