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Description

Structurally it is ACTH 4-7 (Met-Glu-His-Phe), the melanocortin core of adrenocorticotropic hormone, extended at the C-terminus with Pro-Gly-Pro

McKinnell JA, Kunz DF, Chamot E, Patel M, Shirley RM, Moser SA, et al

10.1007/s10557-023-07475-8 28

Singh A, Cresci GA, Kirby DF

The content is solely the responsibility of the authors and does not necessarily represent the official views of the RSNA R&E Foundation

Specifically, Toll-like receptor (TLR) engagement by pathogen-associated molecular patterns (PAMPs) activates RIPK3 via the adapter proteins TRIF or ZBP1, thereby bypassing RIPK1 to directly promote MLKL phosphorylation and execute the necroptotic death program