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You know, you should be able to show some amount of improvement in two weeks at four weeks if you haven't shown significant improvement we then refer to it as a recalcitrant wound and then we you know, we do a lot of midcourse adjustments sometimes it's not obvious what the cause is and it takes us some time to do the work up and we have to take a careful history

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In the melanoma model, BPC-157 suppressed Ki-67 expression, a marker associated with cell proliferation, and downregulated VEGF in tumor cells

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The first phase is especially sensitive to movement and stress