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Eutopic versus ectopic comparison often led to a high number of DMPs/DMRs which may be skewed by cell-type proportions

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Interestingly, male patients with inflammatory bowel disease (IBD) exhibit downregulated GPER expression in intestinal tissue, accompanied by elevated proinflammatory cytokine levels, whereas female patients are more likely to benefit from GPER agonists, which increase anti-inflammatory signaling and reduce intestinal inflammation [76]

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Individuals hospitalized with acute mania have increased exposure to antimicrobial medications

Some research suggests that accelerated epigenetic aging is associated with higher mortality risk