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Importantly, deletion of eosinophil-derived IL-4 only ameliorated lesion development, without preventing disease progression (Lee et al, 2020

doi: 10.1016/j.chembiol.2021.05.013 220 MaXZhaoHSongJKZhangZGaoCJLuoYet al

Activation of IP receptors leads to G-protein-mediated activation of adenylate cyclase, which in turn catalyzes the formation of cyclic adenosine monophosphate (cAMP) [65]

10.1155/2022/5861553 256 ZhaoL.SongC.HuangY.LeiW.SunJ

no rejection (Fig1B), top transcripts in biopsies included IL18BP, GBP5, and IFNG (P=2.0E-8 to 4.8E-6)

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