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10.1007/s10853-008-3060-9 148

Gut 65 , 13591368 (2016)

In the future, the integration of metabolomic readouts, single-cell and spatial transcriptomic localization, and metabolic modeling analysis is expected to establish a research framework of metabolic stratification-target selection-efficacy prediction, thereby reducing the risk of failed extrapolation across different diseases or populations (138)

Furthermore, toll-like receptor (TLR)-mediated signals markedly increase Glut1 expression and glycolytic rates, which is detrimental to the stability and suppressive capacity of Treg cells [154]

It is reasonable to utilize screening instruments for these disorders in routine practice and then arrange formal consultation when screening or symptoms suggest a psychiatric component to a patient's WD