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This process is thought to be due to accumulation of mutations in cancer-related genes, including oncogenes, tumor-suppressor genes, and DNA mismatch repair (MMR) genes

While PSP diagnosis typically relies on clinical features, neuroimaging and response to levodopa can provide further diagnostic support

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However, other (TBK1-independent) activities of mutant p53 may also affect the tumor microenvironment

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This generally is not critical in testing male Caucasians, but it certainly is a problem in diagnosing some Caucasian females and blacks of both sexes, especially during the reticulocytosis following acute hemolysis