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Inhibition of bile acid (BA) transporters is a potential therapeutic option to treat NASH by restoring lipid homeostasis and reducing inflammatory burden

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10.3390/nu13082567 [DOI] [PMC free article] [PubMed] [Google Scholar] 230.Puchalska P, Crawford PA

The use of a multiplexing approach with a robust CRISPR/Cas9 array having single or multiple sgRNAs or RNPs targeting conserved sequences of target genes and protoplast-mediated transformation could be deployed for precision editing