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Moreover, in an ischemic state, the mitochondrial imbalance ensues

In this context, NRF2 knockout diminished inorganic arsenic-induced HIF-1 accumulation and stemness marker expression

Other oxidative stress triggers include a poor diet, low physical activity, prolonged stress, and intrinsic factors, such as mitochondrial dysfunction leading to reduced adenosine 5-triphosphate (ATP) production, inflammation, and hypoxia (106, 117)

10.1016/j.it.2021.05.004 225 Pratap-SinghA.GuoY.BaldelliA.SinghA

Therefore, the low, sustained levels of NO often found in the CRC tumor microenvironment may confer a survival advantage by protecting cancer cells against ferroptotic stress

doi:10.1038/s41588-020-00753-3