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The extracts and major compounds derived from astragali Radix alter mitochondrial bioenergetics in cultured cardiomyocytes: Comparison of various polar solvents and compounds

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We first determined whether ML226 and DEG had similar effects on 2-OGDDs and examined PHD activity (HIF-1 stabilization), TET activity (DNA 5-hydroxymethylcytosine (5hmC) levels) and KDM activity (histone lysine methylation marks)

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The matrix also contains antioxidant systems, including the glutathione peroxidase (GPx)/glutathione reductase (GR) cycle, which detoxifies H 2 O 2