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and lower affinity coordinating copper by imidazole nitrogen of His sidechain, the amide nitrogens of Val49 and His50 and a water molecule 20

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doi: 10.1038/ismej.2017.118 118 NingY.JantasuriyaratC.ZhaoQ.ZhangH.ChenS.LiuJ.et al

Figure 4 One limitation of examining these clinical trial data in this way is that the ASD population that received the placebo, although similar in development, age and gender, for various reasons, had some differences baseline metabolic characteristics which could affect the effectiveness of the treatment being studied