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The usual dosages used in clinical studies range from 250 mg to 6 g per day (NatMed 2025)

However, in an agonist-bound state such as was seen in the crystal structure of DHT-bound AR (PDB: 1I37 or 2AMA), H12 was held near H3 and H4 (Figure 3D)

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studied the sensitivity of tumor cells to mitochondrial ETC inhibitors and found that tumor cells insensitive to ETC inhibition maintain intracellular Asp concentrations through the Asp/glutamate transporter SLC1A3, which gives tumor cells a survival advantage

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