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Together, they generate malignant cell populations with distinct biological properties, evolutionary fitness, and therapeutic sensitivities ( Figure 1 2 Intertumoral and intratumoral heterogeneity: distinct but interconnected dimensions Intertumoral heterogeneity refers to phenotypic and molecular variation between tumors arising in different patients with the same histopathological diagnosis

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Our current understanding of related pathology in AD-NPS points to potential therapeutic targets, such as the monoaminergic system (Delgado, 2000)

8 QM/MM calculations of the Pt GSTF8 wild-type and C13S reaction pathways

Cobalt-related cardiomyopathy: A real concern

Additional contributing factors include increased expression of insulin-like growth factor 1 (IGF1) receptors, IGF1-binding protein (which protects IGF1 from proteolysis) in Purkinje cells [8], as well as upregulated mRNA expression of GLUT1 and GLUT3 [80]