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ORCID: Affiliation: 8 Neuroscience Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney NSW 2006, Australia 9 Laboratory of Neurobiology and Pathological Physiology, Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 602 00 Brno, Czech Republic These authors contributed equally to this work

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However, in addition to these reversible modifications, several cysteine adducts can form irreversibly due to prolonged exposure of cysteine residues to ROS and RNS, such as sulfinic or sulfonic acids (Chouchani et al., 2011

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By applying it to the affected joint or muscle, patients get high local drug concentration exactly at the pain site