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All 20 prioritised variants were poorly represented in the GRCh38 reference genome

It's enforced at the data layer

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Lysates were diluted to final concentrations of 200 mM NaCl, 0.5% NP-40, and 0.05% Na-deoxycholate, and incubated with GFP-binding protein (GBP) beads for 2 h at 4 C

3F), indicating that replenishing ER Ca 2+ stores can re-sensitize cells

Endothelial cells are then perfused at low flow through the channel compartment to achieve endothelialization and establish a perfusable microvascular bed