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Until there is greater adherence among investigators to an accepted standard of reporting chemical composition of samples, likely using TQ content as a starting point, this issue cannot be adequately resolved

They reported that the prevalence of SELENOP-aAb in CFS was about 10 times elevated in comparison to controls and exceeded that reported in thyroid or cancer patients

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Designing prodrugs that are inactive in the systemic circulation but are selectively activated by enzymes overexpressed in diseased tissues (e.g., cathepsins and matrix metalloproteinases) allows for the localized release of active copper-modulating agents, thereby minimizing off-target effects [257]

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