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If the cause is absorption failure (pernicious anemia, gastric surgery), intramuscular B12 injections bypass the gut

However, there was no overall improvement in depression symptoms, pain scores or in the results of a 12-item short form health survey

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Ghosh, S

While B12 injections are generally considered safe, its important to be aware of potential side effects, which are typically mild and may include: Mild pain or redness at the injection site Temporary itching or rash Diarrhea or upset stomach Headache These side effects are usually short-lived and resolve on their own